Well not really, after using divs to layout my web pages for some time now I decided to try the 960 CSS Framework. It's a welcome change from doing a load of floats.
I recommend reading Stefan Vervoort's post on divitodesign to get started, there are also some good examples provided in the downloadable zip.
This is purely a layout framework which helps you separate your content into columns of 60px, I know of other CSS frameworks that do a lot more.
What CSS frameworks do you know of and/or use?